Pronunciation: COL-a-geh-nase klo-STRID-ee-um his-toe-LIT-ik-um
Generic Name: Collagenase Clostridium Histolyticum
Brand Name: Xiaflex
Collagenase Clostridium Histolyticum is used for:
Treating Dupuytren contracture with a palpable cord.
Collagenase Clostridium Histolyticum is a collagenase enzyme. It works by helping to break down the collagen in the cord, which allows the fingers to straighten.
Do NOT use Collagenase Clostridium Histolyticum if:
- you are allergic to any ingredient in Collagenase Clostridium Histolyticum
Contact your doctor or health care provider right away if any of these apply to you.
Before using Collagenase Clostridium Histolyticum:
Some medical conditions may interact with Collagenase Clostridium Histolyticum. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a bleeding problem
Some MEDICINES MAY INTERACT with Collagenase Clostridium Histolyticum. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Medicines that thin the blood (eg, aspirin, clopidogrel, prasugrel, warfarin) because the risk of bleeding or bruising at the injection site may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Collagenase Clostridium Histolyticum may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Collagenase Clostridium Histolyticum:
Use Collagenase Clostridium Histolyticum as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Collagenase Clostridium Histolyticum comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Collagenase Clostridium Histolyticum refilled.
- Collagenase Clostridium Histolyticum is usually given as an injection at your doctor's office, hospital, or clinic.
- Do not bend or straighten the fingers of your hand until your doctor tells you to. This will help prevent the medicine from leaking out of the cord.
- Do NOT try to straighten the finger yourself.
- Keep the treated hand elevated until bedtime.
- If you miss your dose of Collagenase Clostridium Histolyticum, contact the doctor to set up a new appointment.
Ask your health care provider any questions you may have about how to use Collagenase Clostridium Histolyticum.
Important safety information:
- You will need to return to your doctor's office the day after you receive Collagenase Clostridium Histolyticum for an examination of the treated hand. Your doctor may also need to straighten your finger. Do not try to straighten the finger yourself.
- Do not perform normal activities with the treated hand until your doctor tells you otherwise.
- You will need to wear a splint at bedtime for up to 4 months after you receive Collagenase Clostridium Histolyticum.
- Your doctor will give you exercises for the treated hand. Discuss any questions that you may have about these exercises with your doctor.
- Rarely, some patients have had serious effects on other tissues of the treated hand (eg, tendon or ligament problems, nerve problems). Tell your doctor right away if you have numbness, tingling, or increased pain in the treated finger or hand after your injection or after your follow-up visit. Also tell your doctor if you have trouble bending your treated finger after the swelling goes down or if you have problems using the treated hand after your follow-up visit.
- Collagenase Clostridium Histolyticum should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Collagenase Clostridium Histolyticum while you are pregnant. It is not known if Collagenase Clostridium Histolyticum is found in breast milk. If you are or will be breast-feeding while you use Collagenase Clostridium Histolyticum, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Collagenase Clostridium Histolyticum:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Mild swelling or pain of the lymph nodes in the elbow or underarm; pain, redness, bruising, or mild bleeding at the injection site; swelling, pain, or tenderness of the treated hand; warmth or redness of the skin.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness or pain in the chest; swelling of the mouth, face, lips, or tongue); fainting; numbness, tingling, or other unusual sensation in the treated hand; severe or persistent bleeding at the injection site; severe pain in the treated area; symptoms of infection (eg, fever, chills, swelling, redness); trouble bending the treated finger after the swelling goes down; trouble using the treated hand.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Collagenase Clostridium Histolyticum side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Proper storage of Collagenase Clostridium Histolyticum:
Collagenase Clostridium Histolyticum is usually handled and stored by a health care provider. If you are using Collagenase Clostridium Histolyticum at home, store Collagenase Clostridium Histolyticum as directed by your pharmacist or health care provider.
General information:
- If you have any questions about Collagenase Clostridium Histolyticum, please talk with your doctor, pharmacist, or other health care provider.
- Collagenase Clostridium Histolyticum is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Collagenase Clostridium Histolyticum. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Collagenase Clostridium Histolyticum resources
- Collagenase Clostridium Histolyticum Side Effects (in more detail)
- Collagenase Clostridium Histolyticum Use in Pregnancy & Breastfeeding
- Collagenase Clostridium Histolyticum Drug Interactions
- Collagenase Clostridium Histolyticum Support Group
- 0 Reviews for Collagenase Clostridium Histolyticum - Add your own review/rating
- Collagenase Clostridium Histolyticum Professional Patient Advice (Wolters Kluwer)
- collagenase clostridium histolyticum Injection Advanced Consumer (Micromedex) - Includes Dosage Information
- Xiaflex Prescribing Information (FDA)
- Xiaflex Consumer Overview
Compare Collagenase Clostridium Histolyticum with other medications
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